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Related Concept Videos

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...

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A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model
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Cryptococcal sepsis in small vessel vasculitis.

S Satish1, R Rajesh, S Shashikala

  • 1Department of Nephrology, Amrita Institute of Medical Sciences and Research Center, Kochi, Kerala, India.

Indian Journal of Nephrology
|November 13, 2010
PubMed
Summary
This summary is machine-generated.

Disseminated cryptococcosis, a rare fungal infection outside of advanced HIV, occurred in a patient with Wegener's granulomatosis. This case highlights the risk of invasive cryptococcosis in patients on immunosuppressive therapy.

Keywords:
CryptococcemiaWegener’s granulomatosiscryptococcemiaimmunosupression

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Last Updated: Jun 6, 2026

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Area of Science:

  • Infectious Diseases
  • Immunology
  • Rheumatology

Background:

  • Disseminated cryptococcosis and cryptococcemia are typically observed in patients with advanced Human Immunodeficiency Virus (HIV) infection.
  • Meningoencephalitis caused by Cryptococcus is a known opportunistic infection in immunocompromised individuals.

Observation:

  • This report details a rare case of disseminated cryptococcosis and cryptococcemia.
  • The patient presented with Wegener's granulomatosis, a systemic vasculitis.
  • The patient was undergoing immunosuppressive therapy for Wegener's granulomatosis.

Findings:

  • Disseminated cryptococcosis occurred in an immunocompromised patient without advanced HIV infection.
  • Wegener's granulomatosis and its immunosuppressive treatment were associated with invasive cryptococcosis.

Implications:

  • This case underscores the potential for invasive fungal infections like cryptococcosis in non-HIV immunocompromised patients.
  • Physicians should consider cryptococcosis in the differential diagnosis of infections in patients with autoimmune diseases on immunosuppressants.
  • Expanded surveillance for fungal infections may be warranted in specific immunocompromised populations.