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Plasma fibronectin concentrations in blood products
J Perttilä1, M Salo, O Peltola
1Department of Anaesthesiology, University of Turku, Finland.
Intensive Care Medicine
|January 1, 1990
Summary
Cryoprecipitate offers the highest plasma fibronectin concentrations, making it ideal for treating fibronectin deficiency. Fresh whole blood and fresh frozen plasma can also help increase low fibronectin levels.
Area of Science:
- Immunology
- Hematology
Background:
- Plasma fibronectin is a key opsonic protein within the mononuclear phagocyte system (MPS).
- Understanding fibronectin levels in blood products is crucial for transfusion medicine.
Purpose of the Study:
- To quantify plasma fibronectin concentrations in various blood products.
- To determine the most effective blood product for fibronectin replacement therapy.
Main Methods:
- Measurement of plasma fibronectin concentrations.
- Analysis of stored whole blood, fresh whole blood, fresh frozen plasma, and AHG cryoprecipitate.
Main Results:
- Stored whole blood showed the lowest fibronectin levels (151 ± 50 mg/l).
- Fresh whole blood plasma (227 ± 66 mg/l) and fresh frozen plasma (224 ± 78 mg/l) had similar, significantly higher concentrations than stored blood (p < 0.05).
- AHG cryoprecipitate exhibited markedly higher fibronectin concentrations (3249 ± 502 mg/l) (p < 0.001).
Conclusions:
- Cryoprecipitate is the most effective product for correcting fibronectin deficiency due to its high fibronectin content.
- Fresh whole blood and fresh frozen plasma can also be utilized to elevate depressed fibronectin levels.