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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
The hazards of iron loading
1Department of Biology and Program in Medical Sciences, Indiana University, Bloomington, IN 47405, USA. eweinber@indiana.edu
Abstract:
Excessive or misplaced tissue iron now is recognized to pose a substantial health risk for an extensive array of endocrinological, gastrointestinal, infectious, neoplasmic, neurodegenerative, obstetric, ophthalmic, orthopedic, pulmonary and vascular diseases. Ingested, injected, inhaled and decompartmentalized iron contributes not only to disease, but also to aging and mortality. Iron is dangerous by catalyzing free radical formation and by serving as an essential nutrient for microbial and neoplasmic cell invaders. Our body cells exhibit wide variation in sensitivity to iron toxicity. Efficacy of our iron withholding defense system is modulated by numerous environmental, behavioral and genetic factors. A notable variety of methods for prevention and therapy of iron toxicity are now becoming available.
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