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Updated: Jun 6, 2026

Synthesis and Evaluation of a Ruthenium-based Mitochondrial Calcium Uptake Inhibitor
Published on: October 26, 2017
Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(II) complexes
Michelle J Pisani1, Daniel K Weber, Kirsten Heimann
1School of Physical, Environmental and Mathematical Sciences, University of New South Wales, Australian Defence Force Academy, Canberra, ACT 2600, Australia.
Abstract:
The lipophilic ligand-bridged dinuclear cation Rubb₁₆ is significantly cytotoxic and preferentially accumulates in the mitochondria of the L1210 murine leukemia cancer cell line.
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