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Related Concept Videos

Hydrogen Bonds01:04

Hydrogen Bonds

A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
Hydrogen Bonds00:26

Hydrogen Bonds

Hydrogen BondsHydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.Hydrogen Bonds Control the World!Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are...
Intermolecular Forces03:13

Intermolecular Forces

Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen bonds, and dispersion...
Intermolecular Forces03:13

Intermolecular Forces

Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen bonds, and dispersion...
Potential Due to a Magnetized Object01:24

Potential Due to a Magnetized Object

Magnetic dipoles in magnetic materials are aligned when placed under an external magnetic field. For paramagnets and ferromagnets, dipole alignment occurs in the direction of the magnetic field. However, the dipoles align opposite to the field in the case of diamagnets. This state of magnetic polarization due to the external field is called magnetization. Magnetization is defined as the dipole moment per unit volume. It plays a similar role to polarization in electrostatics.
The vector...
Intermolecular vs Intramolecular Forces03:00

Intermolecular vs Intramolecular Forces

Intermolecular forces (IMF) are electrostatic attractions arising from charge-charge interactions between molecules. The strength of the intermolecular force is influenced by the distance of separation between molecules. The forces significantly affect the interactions in solids and liquids, where the molecules are close together. In gases, IMFs become important only under high-pressure conditions (due to the proximity of gas molecules). Intermolecular forces dictate the physical properties of...

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Related Experiment Video

Updated: Jun 6, 2026

Optimized Setup and Protocol for Magnetic Domain Imaging with In Situ Hysteresis Measurement
09:43

Optimized Setup and Protocol for Magnetic Domain Imaging with In Situ Hysteresis Measurement

Published on: November 7, 2017

Hydrogen-bond strengths by magnetically induced currents.

Heike Fliegl1, Olli Lehtonen, Dage Sundholm

  • 1Department of Chemistry, University of Helsinki, P.O. Box 55 (A.I. Virtanens plats 1), FI-00014 Helsinki, Finland.

Physical Chemistry Chemical Physics : PCCP
|November 13, 2010
PubMed
Summary

We developed a non-invasive computational method to measure hydrogen bond strength using magnetically induced currents. This technique was validated on DNA and enzyme models, offering new insights into molecular interactions.

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Chemical Vapor Deposition of an Organic Magnet, Vanadium Tetracyanoethylene
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Chemical Vapor Deposition of an Organic Magnet, Vanadium Tetracyanoethylene

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Optimized Setup and Protocol for Magnetic Domain Imaging with In Situ Hysteresis Measurement
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Area of Science:

  • Computational chemistry
  • Biophysics
  • Molecular interactions

Background:

  • Hydrogen bonds are crucial in biological systems, but quantifying their strength non-invasively is challenging.
  • Existing methods for hydrogen bond strength estimation often require invasive experimental procedures or complex calculations.

Purpose of the Study:

  • To introduce a novel computational approach for estimating hydrogen bond strength.
  • To demonstrate the applicability of this method to biologically relevant systems like DNA and enzymes.

Main Methods:

  • The study employs magnetically induced currents to calculate hydrogen bond strength.
  • The computational method was calibrated using established hydrogen-bonding dimers.
  • The approach was applied to Watson-Crick DNA base pairs and proton wires in carbonic anhydrase.

Main Results:

  • The computational method successfully estimated hydrogen bond strengths in the tested systems.
  • Magnetically induced currents provide a viable metric for hydrogen bond strength quantification.
  • The method shows promise for studying hydrogen bonding in complex biological molecules.

Conclusions:

  • This non-invasive computational method offers an efficient way to determine hydrogen bond strength.
  • The technique advances our ability to study molecular interactions in DNA and enzyme catalysis.
  • Further applications in structural biology and drug design are anticipated.