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Multi-Modal Home Sleep Monitoring in Older Adults

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Cognitive function in elderly marathon runners: cross-sectional data from the marathon trial (APSOEM).

Robert Winker¹, Ina Lukas, Thomas Perkmann

¹Unit of Occupational Medicine, Medical University of Vienna, Vienna, Austria. robert.winker@meduniwien.ac.at

Wiener Klinische Wochenschrift

|November 13, 2010

Summary

Intensive endurance exercise may help older adults maintain cognitive function. However, this benefit doesn't appear to be linked to increased brain-derived neurotrophic factor (BDNF) or insulin-like growth factor (IGF).

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Published on: February 14, 2014

Area of Science:

Gerontology
Neuroscience
Exercise Physiology

Background:

Cognitive impairment is a significant issue for aging populations, impacting quality of life and work ability.
Maintaining cognitive function in the elderly presents a major challenge for Occupational Medicine.

Purpose of the Study:

To investigate the association between intensive endurance exercise and cognitive performance in the elderly.
To determine if endurance training increases brain-derived neurotrophic factor (BDNF) and insulin-like growth factor (IGF).

Main Methods:

Recruited active elderly marathon runners/cyclists (age > 60) and matched them with inactive controls.
Assessed cognitive function using the Vienna Neuropsychological Test Battery and CERAD test battery.
Measured levels of BDNF, IGF-1, Apo e4 carrier status, and self-ratings.

Main Results:

The endurance exercise group showed better performance in one specific cognitive task (Five Point Test, p=0.04) and a near-significant improvement in another (NAI Stroop Test, p=0.08).
No correlation was found between BDNF or IGF-1 levels and exercise duration.
Basal levels of BDNF and IGF-1 did not differ between the exercise and control groups.
Significantly decreased BDNF levels were observed in individuals with a family history of Alzheimer's disease, despite maintained cognitive performance.

Conclusions:

Extensive endurance exercise training may support cognitive function maintenance in older adults.
The cognitive benefits of endurance training in this study were not associated with increased BDNF or IGF-1.
Reduced BDNF levels in individuals with a family history of Alzheimer's disease suggest a potential precursor role for BDNF reduction in cognitive decline.