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Related Concept Videos

Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.
Inflammation01:38

Inflammation

Overview
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...

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Related Experiment Video

Updated: Jun 6, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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Published on: May 21, 2018

Inflammasomes: current understanding and open questions.

Franz Bauernfeind1, Andrea Ablasser, Eva Bartok

  • 1Unit for Clinical Biochemistry, Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany.

Cellular and Molecular Life Sciences : CMLS
|November 13, 2010
PubMed
Summary
This summary is machine-generated.

The innate immune system uses pattern recognition receptors to detect threats. This review details inflammasome activation, focusing on NLRP3 signaling and AIM2 DNA sensing mechanisms.

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Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • The innate immune system detects pathogens and damage using conserved receptors.
  • Nucleotide-binding domain leucine-rich repeat (NLR) proteins form inflammasomes, crucial for inflammation.
  • Inflammasome activation leads to caspase-1 cleavage and secretion of pro-inflammatory cytokines like IL-1β and IL-18.

Purpose of the Study:

  • To review current knowledge on inflammasome activation mechanisms.
  • To focus on the regulatory mechanisms of NLRP3 inflammasome signaling.
  • To highlight recent advancements in DNA sensing by the AIM2 inflammasome receptor.

Main Methods:

  • Literature review of inflammasome research.
  • Analysis of molecular mechanisms regulating inflammasome activation.
  • Synthesis of recent findings on NLRP3 and AIM2 inflammasomes.

Main Results:

  • Inflammasomes are key mediators of inflammatory responses.
  • NLRP3 inflammasome activation mechanisms remain under investigation.
  • AIM2 inflammasome activation is linked to DNA sensing.

Conclusions:

  • Understanding inflammasome activation is critical for innate immunity research.
  • Further research into NLRP3 signaling is needed.
  • AIM2 receptor's role in DNA sensing offers new insights into inflammasome function.