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Selective increase in S-100 beta protein by aging in rat cerebral cortex
K Kato1, F Suzuki, R Morishita
1Department of Biochemistry, Institute for Developmental Research, Aichi, Japan.
Journal of Neurochemistry
|April 1, 1990
Summary
As rats age, the S-100 beta protein concentration increases in the cerebral cortex, indicating a link between this glial marker and age-related central nervous system (CNS) changes.
Area of Science:
- Neuroscience
- Biochemistry
- Aging Research
Background:
- The central nervous system (CNS) undergoes age-related changes.
- Specific protein markers may reflect these alterations.
Purpose of the Study:
- To investigate age-dependent changes in nervous tissue-related proteins in rat CNS.
- To determine the relationship between S-100 beta protein and CNS aging.
Main Methods:
- Enzyme immunoassay was used to quantify protein concentrations.
- Proteins analyzed included S-100 proteins, enolase isozymes, and GTP-binding proteins.
- Rats aged from 2 to 30 months were studied.
Main Results:
- Brain weight and soluble protein concentrations remained constant with age.
- S-100 beta protein concentration significantly increased in the cerebral cortex with age.
- S-100 beta levels in the cerebellum and brainstem were stable.
- Other neuronal and glial marker proteins showed no significant age-related changes.
Conclusions:
- Age-dependent increases in S-100 beta protein are specific to the cerebral cortex.
- S-100 beta protein levels correlate with age-related changes in CNS function, particularly in the cerebral cortex.