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New cytotoxic prostanoids from Taiwanese soft coral Clavularia viridis
Ya-Ching Shen1, Kuang-Liung Lo, Jiun-Yang Chang
1School of Pharmacy, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road Sect. 1, Taipei, Taiwan, Republic of China. ycshen@ntu.edu.tw
Abstract:
Chemical investigation of the AcOEt/MeOH extract of Clavularia viridis collected in Taiwan has afforded four new prostanoids, named claviridins A-D (1-4, resp.). The structures of compounds 1-4 were determined on the basis of 1D- and 2D-NMR techniques, including COSY, HMQC, HMBC, and NOESY experiments. Pharmacological studies revealed that compounds 1-4 exhibited potent cytotoxicity against human cancer cells.
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