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Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
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Antihyperlipidemic agents cause a decrease in von Willebrand factor levels in pediatric patients with familial

S Songül Yalçin1, Bülent Güneş, Sule Unal

  • 1Hacettepe University Faculty of Medicine Department ofPediatrics, 06100, Ankara, Turkey. siyalcin@hacettepe.edu.tr

Journal of Pediatric Endocrinology & Metabolism : JPEM
|November 16, 2010
PubMed

Familial hyperlipidemia is a group of genetic disorders with a predisposition to atherosclerosis. Hyperlipidemia causes increased atherosclerotic events through increased endothelial damage. In this report we aimed to measure the plasma fibrinogen and von Willebrand factor antigen (VWf:Ag) levels in pediatric patients with familial hyperlipidemias and to investigate the effects of serum lipid levels and antihyperlipidemic agents on these parameters. Of the 41 patients analyzed, vWf:Ag level was significantly lower in antihyperlipidemic receivers (132 +/- 51%, 102 +/- 19%; p = 0.010). This finding may indicate that early initiation of antihyperlipidemics in patients with familial hyperlipidemias may decrease the risk of future atherosclerotic events through not only decreasing the serum lipid levels, but also decreasing plasma vWf:Ag levels.

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