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Updated: Jun 6, 2026

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
Published on: May 12, 2023
Stabilizing G-quadruplex DNA by a scissors-shaped binaphthyl derivative through the entangling mode: cooperation of
Hong Zhang1, Jun-Feng Xiang, Hai-Yu Hu
1Beijing National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Chinese Academy of Sciences, Beijing 100190, China.
Abstract:
A scissors-shaped binaphthyl derivative (NPA) has been found to stabilize the G-quadruplex by intertwisting the whole G-quadruplex with two long chains, through the cooperation of the two functional groups: binaphthylene and the ethoxy chain. Moreover, NPA exhibits a good inhibitory effect of telomerase activity as well as excellent cytotoxic activity against HepG-2 human liver cancer cells.
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