Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Regression Toward the Mean01:52

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Child Development Interventions Among Indigenous Peoples in Australia, Canada, New Zealand, and the United States: A Scoping Review.

Children (Basel, Switzerland)·2026
Same author

Knowledge + Innovation = Power: A protocol for implementing Aboriginal data sovereignty in an Aboriginal Medical Service for service delivery reform.

PloS one·2025
Same author

The role of public health professionals in addressing the health and humanitarian catastrophe in Gaza.

BMJ global health·2025
Same author

Supporting healthy lifestyles for First Nations women and communities through co-design: lessons and early findings from remote Northern Australia.

Frontiers in clinical diabetes and healthcare·2024
Same author

Randomised controlled trial of perinatal vitamin D supplementation to prevent early-onset acute respiratory infections among Australian First Nations children: the 'D-Kids' study protocol.

BMJ open respiratory research·2023
Same author

The Role of Accurate Self-Assessments in Optimizing Mate Choice.

Personality & social psychology bulletin·2022

Related Experiment Video

Updated: Jun 6, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Variability in paediatric outcomes within wealthy countries.

Fiona Stanley1, Amanda Langridge, Heather D'Antoine

  • 1Telethon Institute for Child Health Research, The University of Western Australia, Australia. fiona@ichr.uwa.edu.au

Acta Paediatrica (Oslo, Norway : 1992)
|November 16, 2010
PubMed
Summary
This summary is machine-generated.

Preterm birth risks and outcomes differ significantly in Aboriginal populations. These findings may offer insights for addressing similar disparities in immigrant populations globally, promoting equitable pediatric care.

Related Experiment Videos

Last Updated: Jun 6, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Area of Science:

  • Perinatal epidemiology
  • Public health
  • Indigenous health

Background:

  • Preterm birth is a major global health concern with significant disparities.
  • Existing research often overlooks specific risks within Indigenous subpopulations.

Purpose of the Study:

  • To analyze preterm birth risks and outcomes in Western Australia's Aboriginal population.
  • To explore potential causes of observed disparities.
  • To propose strategies for minimizing these disparities in a global context.

Main Methods:

  • Retrospective analysis of birth data from Western Australia.
  • Comparative risk assessment between Aboriginal and non-Aboriginal subpopulations.
  • Identification of key contributing factors to preterm birth.

Main Results:

  • Significantly elevated risks of preterm birth identified in the Aboriginal subpopulation.
  • Distinct patterns in preterm birth outcomes observed within this group.
  • Potential socioeconomic and healthcare access factors implicated.

Conclusions:

  • The study highlights critical, underrecognized disparities in preterm birth for Indigenous populations.
  • Findings suggest these patterns may be relevant to immigrant populations in developed countries.
  • A different approach is needed to address universal pediatric issues and reduce health inequities.