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Updated: Jun 6, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
Wound healing primer
Stephanie R Goldberg1, Robert F Diegelmann
1Department of Surgery, Virginia Commonwealth University Medical Center, West Hospital, 16th Floor, West Wing, 1200 East Broad Street, Richmond, VA 23298-0645, USA.
Abstract:
Surgeons often care for patients with conditions of abnormal wound healing, which include conditions of excessive wound healing, such as fibrosis, adhesions, and contractures, as well as conditions of inadequate wound healing, such as chronic nonhealing ulcers, recurrent hernias, and wound dehiscences. Despite many recent advances in the field, which have highlighted the importance of adjunct therapies in maximizing the healing potential, conditions of abnormal wound healing continue to cause significant cost, morbidity, and mortality. To understand how conditions of abnormal wound healing can be corrected, it is important to first understand the basic principles of wound healing.
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