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Shining a light on germinal center B cells

Jason G Cyster1

  • 1Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA. jason.cyster@ucsf.edu

Cell
|November 16, 2010
PubMed

The mechanisms of B cell selection in lymphoid tissues are poorly understood. In this issue, Victora et al. (2010) use imaging of photoactivatable green fluorescent protein to define the movements of B cells in germinal centers and provide evidence that antibody affinity maturation is driven by competition for T cell help.

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