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Updated: Jun 6, 2026
09:04
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Pyridylmethylthio derivatives as VEGF inhibitors. Part 1
Hisashi Tajima1, Takahiro Honda, Kenji Kawashima
1Research and Development Center, Santen Pharmaceutical Co. Ltd, Ikoma-shi, Nara, Japan. hisashi.tajima@santen.co.jp
Bioorganic & Medicinal Chemistry Letters
|November 16, 2010
Abstract:
Optimization from compound 4a, having intramolecular S-O nonbonded interaction, led to discover compounds 4m and 4n. They were highly active in vitro (VEGF induced HUVEC proliferation assay) and showed efficacies in three disease models in vivo (cancer, RA, AMD).
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