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Inactive yet indispensable: the tale of Jarid2
David Landeira1, Amanda G Fisher
1Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
Trends in Cell Biology
|November 16, 2010
Summary
Histone methylation guides gene expression. Jarid2, a chromatin modifier, is crucial for organ development and embryonic stem (ES) cell differentiation, despite lacking catalytic activity.
Area of Science:
- Developmental Biology
- Epigenetics
- Molecular Biology
Background:
- Histone tail methylation is vital for gene expression.
- Jarid2 is a chromatin modifier with potential histone demethylase activity.
- Jarid2 is essential for organ development in mice.
Purpose of the Study:
- To discuss the literature on Jarid2 function.
- To hypothesize the role of Jarid2 in gene priming during development.
Main Methods:
- Literature review of Jarid2 function.
- Analysis of Jarid2's role in Polycomb Repressive Complex 2.
- Examination of Jarid2's necessity in embryonic stem cell differentiation.
Main Results:
- Jarid2 is a component of Polycomb Repressive Complex 2.
- Jarid2 is required for embryonic stem cell differentiation.
- Jarid2's catalytic activity is thought to be abolished.
Conclusions:
- Jarid2 deficiency may result from impaired gene priming in ES cells.
- Proper gene priming by Jarid2 is critical for later developmental stages.
- Jarid2's non-catalytic function is essential for developmental processes.
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