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Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
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Published on: July 14, 2010

Inhibition of JNK phosphorylation reverses memory deficit induced by β-amyloid (1-42) associated with decrease of

Mahmoudreza Ramin1, Pegah Azizi, Fereshteh Motamedi

  • 1Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Behavioural Brain Research
|November 16, 2010
PubMed
Summary

Inhibiting JNK (c-Jun N-terminal kinase) in rats with Alzheimer's disease models improved spatial memory. This suggests JNK inhibition may offer a new therapeutic strategy for Alzheimer's disease by reducing apoptosis.

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