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Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Prostatic stromal sarcoma with rhabdoid features.

Joo Young Kim¹, Yong Mee Cho, Jae Y Ro

¹Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 138-736 Seoul, Korea.

Annals of Diagnostic Pathology

|November 16, 2010

Summary

This summary is machine-generated.

This report details the first known case of prostatic stromal sarcoma with rhabdoid features in a 31-year-old male. This rare and aggressive tumor exhibited rapid progression and poor prognosis.

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Area of Science:

Oncology
Pathology
Urologic Oncology

Background:

Rhabdoid tumors are aggressive neoplasms found in various sites, often as composite tumors.
Rhabdoid tumors of the prostate are exceptionally rare, with only one prior report suggesting epithelial origin.
Rhabdoid features have not been previously documented in prostatic stromal sarcomas (PSSs).

Observation:

A 31-year-old male presented with voiding difficulties and anal pain due to a prostatic mass invading the rectum and bladder.
Initial biopsy diagnosed unclassified spindle cell sarcoma; neoadjuvant chemotherapy was administered.
Radical prostatectomy revealed a high-grade sarcoma with spindle cells and epithelioid cells exhibiting rhabdoid features.

Findings:

Immunohistochemistry showed positivity for vimentin, CD34, and progesterone receptor in both cell types.
Desmin and cytokeratin were negative, while INI1 expression was retained in rhabdoid cells.
The tumor demonstrated aggressive behavior with recurrence in the bladder and death from sepsis within 7 months.

Implications:

This case represents the first description of prostatic stromal sarcoma with rhabdoid features.
The findings highlight the potential for rhabdoid differentiation in PSS.
This rare entity presents with aggressive clinical behavior and necessitates further investigation into its pathogenesis and treatment strategies.