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Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
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Recombinant factor VIIa in trauma patients without coagulation disorders
Corey Scher1, Venod Narine, Daniel Chien
1Department of Anesthesiology, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467-2490, USA. coreyscher@gmail.com
Anesthesiology Clinics
|November 16, 2010
Summary
Recombinant activated factor VIIa (rFVIIa) offers a valuable option for managing bleeding in various clinical settings. Future research will further refine its use, emphasizing calcium monitoring and optimizing patient conditions for enhanced efficacy.
Area of Science:
- Anesthesiology
- Hematology
- Pharmacology
Background:
- Recombinant activated factor VIIa (rFVIIa) is utilized for bleeding disorders.
- Its application extends to diverse clinical scenarios.
Purpose of the Study:
- To highlight the clinical utility of rFVIIa for anesthesiologists.
- To suggest optimal strategies for rFVIIa administration and monitoring.
Main Methods:
- Review of current clinical applications of rFVIIa.
- Analysis of factors influencing rFVIIa efficacy.
Main Results:
- rFVIIa presents a viable option for managing bleeding states.
- Ongoing studies aim to expand its clinical role.
Conclusions:
- Timing of rFVIIa administration and ionized calcium monitoring are critical.
- Optimizing fibrinogen, platelets, pH, and temperature enhances rFVIIa effectiveness.
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