Related Experiment Video
Updated: Jun 6, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
[Pharmaco-economic optimization of cholesterol-lowering treatment with statins]
Antonio Ruiz García1, Francisco Javier Gordillo López, Ezequiel Arranz Martínez
1Unidad de Lípidos y Prevención Cardiovascular, Centro de Salud Pinto, Dirección Asistencial 4 SUR, SERMAS, Madrid, España. antoniodoctor@gmail.com
Abstract:
Current guidelines for the management of hypercholesterolemia identify LDL cholesterol (LDL-c) reduction as the primary therapeutic target and have highlighted the need to use statins to achieve it. There are six statins with four different doses and with different power-reducing LDL-c. By adding ezetimibe, there are 48 therapeutic possibilities. This extensive offer provides pharmaceutical treatment, but it is difficult to choose the most cost-effective statin because it is very difficult to remember all the powers and costs of treatment options. This paper offers a method to prioritize the best cost-effective lipid lowering, and chooses the cheapest statin that achieves the desired therapeutic goal of LDL-c.
Related Concept Videos
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Atherosclerosis III: Management
Cholesterol: Significance and Regulation
Considering cholesterol and...
Pharmacokinetic–Pharmacodynamic Relationship: Problems
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence