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Timothy D Cushing1, Vijay Baichwal, Karen Berry

  • 1Medicinal Chemistry, Amgen Inc, 1120 Veterans Blvd, South San Francisco, CA 94080, USA. tcushing@amgen.com

Bioorganic & Medicinal Chemistry Letters
|November 16, 2010
PubMed

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...