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Published on: December 29, 2016
Noninflammatory cerebral vasculopathy associated with recurrent ischemic strokes
James S McKinney1, Jonathan M Raser, Miguel A Guzman
1Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA. mckinnjs@umdnj.edu
Abstract:
Recurrent ischemic strokes often have uncommon causes in young adults. Vascular abnormalities may be considered as a possible etiology. We report a 36-year-old man who experienced recurrent cryptogenic ischemic strokes despite medical therapy. Conventional cerebral angiography was unrevealing. Subsequent brain biopsy revealed a distinctive histopathological pattern of abnormal perivascular collagen deposition without inflammation. Recurrent cryptogenic strokes may have novel etiologies, and brain biopsy should be considered when standard diagnostic tests fail.
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