Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antimicrobial Proteins01:23

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Regulation of Bacterial Virulence01:28

Regulation of Bacterial Virulence

Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

miR-3687 Overexpression Promotes Bladder Cancer Cell Growth by Inhibiting the Negative Effect of FOXP1 on Cyclin E2 Transcription.

Molecular therapy : the journal of the American Society of Gene Therapy·2019
Same author

The unique trimeric assembly of the virulence factor HtrA from <i>Helicobacter pylori</i> occurs via N-terminal domain swapping.

The Journal of biological chemistry·2019
Same author

A Novel Synthetic Compound, Bismuth Zinc Citrate, Could Potentially Reduce Cisplatin-Induced Toxicity Without Compromising the Anticancer Effect Through Enhanced Expression of Antioxidant Protein.

Translational oncology·2019
Same author

WITHDRAWN: MicroRNA-107 regulates autophagy and apoptosis of osteoarthritis chondrocytes by targeting TRAF3.

International immunopharmacology·2019
Same author

Clinical efficacy and safety of rituximab in lupus nephritis.

Drug design, development and therapy·2019
Same author

Engineering Na<sub>V</sub>1.7 Inhibitory JzTx-V Peptides with a Potency and Basicity Profile Suitable for Antibody Conjugation To Enhance Pharmacokinetics.

ACS chemical biology·2019
Same journal

Circulating miRNA in metabolic syndrome and cancer: Machinery, diagnostics, and therapeutics.

The international journal of biochemistry & cell biology·2026
Same journal

Corrigendum to "Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels" [Int. J. Biochem. Cell Biol. 42 (2010) 1840-1846].

The international journal of biochemistry & cell biology·2026
Same journal

Whole-brain spatial metabolomics reveals metabolic gradient shifts in a murine glioma model following boron neutron capture therapy (130 characters).

The international journal of biochemistry & cell biology·2026
Same journal

LCN2 modulates Th17/Treg balance in vitro and is associated with an adaptive response to intestinal ischemia-reperfusion injury under Hmox1-deficient conditions.

The international journal of biochemistry & cell biology·2026
Same journal

Chloroquine modulates the redox-sensitive signalling via inhibiting the AMPK-ULK1 under LPS induced state in murine splenic macrophages.

The international journal of biochemistry & cell biology·2026
Same journal

The vicious cycle of hyperglycemia and oxidative stress: Novel mechanistic insights into a pathogenic alliance.

The international journal of biochemistry & cell biology·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Identifying Protein-protein Interaction in Drosophila Adult Heads by Tandem Affinity Purification (TAP)
10:36

Identifying Protein-protein Interaction in Drosophila Adult Heads by Tandem Affinity Purification (TAP)

Published on: December 5, 2013

Vitellogenin, a multivalent sensor and an antimicrobial effector.

Shicui Zhang1, Shaohui Wang, Hongyan Li

  • 1Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China. sczhang@ouc.edu.cn

The International Journal of Biochemistry & Cell Biology
|November 16, 2010
PubMed
Summary
This summary is machine-generated.

Vitellogenin (Vg) is more than just an embryo nutrient; it plays a crucial role in innate immunity. This protein acts as a pattern recognition receptor and bactericidal molecule, offering new insights into host defense mechanisms.

More Related Videos

Avidity-based Extracellular Interaction Screening (AVEXIS) for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions
12:30

Avidity-based Extracellular Interaction Screening (AVEXIS) for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions

Published on: March 5, 2012

Related Experiment Videos

Last Updated: Jun 6, 2026

Identifying Protein-protein Interaction in Drosophila Adult Heads by Tandem Affinity Purification (TAP)
10:36

Identifying Protein-protein Interaction in Drosophila Adult Heads by Tandem Affinity Purification (TAP)

Published on: December 5, 2013

Avidity-based Extracellular Interaction Screening (AVEXIS) for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions
12:30

Avidity-based Extracellular Interaction Screening (AVEXIS) for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions

Published on: March 5, 2012

Area of Science:

  • Immunology
  • Biochemistry
  • Developmental Biology

Background:

  • Vitellogenin (Vg) is traditionally known as the precursor to yolk proteins, vital for nourishing developing embryos.
  • Emerging research indicates Vg possesses functions extending beyond its nutritional role.

Purpose of the Study:

  • To explore the multifaceted roles of Vitellogenin (Vg) in biological systems.
  • To highlight Vg's significance in innate immune responses.
  • To investigate potential applications of Vg in enhancing immunity.

Main Methods:

  • Literature review of recent developments in Vg research.
  • Analysis of Vg's molecular interactions with microbial components.
  • Examination of Vg's properties as an acute phase protein.

Main Results:

  • Vg functions as a multivalent pattern recognition receptor, binding to various microbial molecules like lipopolysaccharide and viral particles.
  • Vg exhibits bactericidal activity, capable of damaging bacterial cell walls.
  • Vg acts as an acute phase protein with bacterial-binding and inhibiting properties, suggesting in vivo immune functions.

Conclusions:

  • Vitellogenin (Vg) plays a significant role in innate immunity, acting as a pattern recognition receptor and bactericidal agent.
  • Further research into Vg and yolk proteins can illuminate host defense mechanisms.
  • Vg and its derivatives may offer novel strategies for boosting immunity in aquaculture and developing embryos.