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Related Experiment Video

Updated: Jun 6, 2026

Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration

Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration

Published on: May 7, 2018

The gastric mucosa development and differentiation.

Shradha Khurana¹, Jason C Mills

¹Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

Progress in Molecular Biology and Translational Science

|November 16, 2010

Summary

This summary is machine-generated.

Gastric mucosa development involves complex signaling pathways and germ layer interactions. Key signaling systems like Hedgehog, Wnt, Notch, BMP, and FGF are crucial for stomach formation and regeneration.

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Establishment and Characterization of Patient-derived Gastric Organoids from Biopsies of Benign Gastric Body and Antral Epithelium

Establishment and Characterization of Patient-derived Gastric Organoids from Biopsies of Benign Gastric Body and Antral Epithelium

Published on: January 26, 2024

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Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration

Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration

Published on: May 7, 2018

Establishment and Characterization of Patient-derived Gastric Organoids from Biopsies of Benign Gastric Body and Antral Epithelium

Establishment and Characterization of Patient-derived Gastric Organoids from Biopsies of Benign Gastric Body and Antral Epithelium

Published on: January 26, 2024

Area of Science:

Developmental biology
Gastroenterology
Molecular signaling

Background:

Gastric mucosa development is a complex process involving reciprocal epithelial-mesenchymal interactions.
The stomach originates from two germ layers: endoderm (epithelium) and mesoderm (smooth muscle).
These interactions are vital for both fetal development and adult tissue regeneration.

Purpose of the Study:

To review discoveries on signaling pathways regulating stomach development across various model systems.
To highlight the roles of specific signaling pathways in gastric organogenesis.

Main Methods:

Review of scientific literature and model system studies (zebrafish to human).
Analysis of key signaling pathways involved in embryonic development and tissue regeneration.

Main Results:

Identified essential roles for Hedgehog, Wnt, Notch, bone morphogenetic protein (BMP), and fibroblast growth factor (FGF) signaling.
Demonstrated the importance of these pathways in different stages of stomach development.

Conclusions:

Hedgehog, Wnt, Notch, BMP, and FGF signaling are critical for gastric development and differentiation.
Understanding these pathways provides insights into stomach formation and regeneration mechanisms.