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Related Concept Videos

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

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Related Experiment Video

Updated: Jun 6, 2026

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses
07:42

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Published on: July 13, 2016

The intestinal stem cell.

Luis A Chia1, Calvin J Kuo

  • 1Cancer Biology Program, Stanford University School of Medicine, Stanford, California, USA.

Progress in Molecular Biology and Translational Science
|November 16, 2010
PubMed
Summary
This summary is machine-generated.

Intestinal stem cells (ISCs) maintain the rapidly regenerating gut lining. Recent discoveries of ISC markers are revealing how their niche regulates them and their potential role in colorectal cancer.

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Related Experiment Videos

Last Updated: Jun 6, 2026

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses
07:42

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Published on: July 13, 2016

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

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Published on: July 27, 2022

The 3D Culturing of Organoids from Murine Intestinal Crypts and a Single Stem Cell for Organoid Research
10:39

The 3D Culturing of Organoids from Murine Intestinal Crypts and a Single Stem Cell for Organoid Research

Published on: April 7, 2023

Area of Science:

  • Gastroenterology
  • Cell Biology
  • Cancer Research

Background:

  • The intestinal epithelium regenerates rapidly, with full turnover every 3-5 days in mice.
  • This regeneration is driven by intestinal stem cells (ISCs) located at the base of crypts.
  • Understanding ISC regulation is crucial, but definitive ISC markers were previously lacking.

Purpose of the Study:

  • To review the literature on the identity and location of ISCs.
  • To explore the role of the niche in ISC maintenance and regulation.
  • To examine the hypothesis that ISCs are the cells of origin for colorectal cancer.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of studies identifying functional stem cell markers.
  • Synthesis of research on ISC niche interactions.

Main Results:

  • Recent identification of specific genes marking functional ISCs has advanced the field.
  • Insights into the regulatory signals from the ISC niche are emerging.
  • ISCs are increasingly implicated as the cells of origin in colorectal cancer.

Conclusions:

  • Definitive ISC markers are key to understanding stem cell regulation.
  • The surrounding niche plays a critical role in maintaining and controlling ISCs.
  • ISCs represent a significant area of study for colorectal cancer origins.