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Changes in plasma müllerian-inhibiting substance and brain-derived neurotrophic factor after chemotherapy in

Muhammad Faisal Aslam1, Zaher O Merhi, Safaa Ahmed

  • 1Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New York 11219, USA. drfaisalaslam@yahoo.co.uk

Fertility and Sterility
|November 16, 2010
PubMed

Eight premenopausal women with cancer had blood drawn for analysis of brain-derived neurotrophic factor (BDNF) and müllerian-inhibiting substance (MIS) before and 3 months after receiving chemotherapy. Unlike MIS, BDNF levels were not reduced after chemotherapy.

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...