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Related Experiment Video

Updated: Jun 6, 2026

Isolating and Imaging Live, Intact Pacemaker Regions of Mouse Renal Pelvis by Vibratome Sectioning
07:38

Isolating and Imaging Live, Intact Pacemaker Regions of Mouse Renal Pelvis by Vibratome Sectioning

Published on: April 30, 2021

Contractility and pacemaker cells in the prostate gland.

Dan-Thanh T Nguyen1, Anupa Dey, Richard J Lang

  • 1Monash Institute of Pharmaceutical Sciences, Parkville and Department of Physiology, Monash University, Clayton, Victoria, Australia.

The Journal of Urology
|November 16, 2010
PubMed
Summary

Prostate stromal tone is generated by specialized c-kit cells, similar to interstitial cells of Cajal in the gut. Understanding these mechanisms is crucial for age-related prostate conditions like benign prostatic hyperplasia.

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Last Updated: Jun 6, 2026

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Preparation and Utilization of Freshly Isolated Human Detrusor Smooth Muscle Cells for Characterization of 9-Phenanthrol-Sensitive Cation Currents

Published on: January 31, 2020

Area of Science:

  • Urology
  • Physiology
  • Cell Biology

Background:

  • Prostate stromal tone is critical for normal function.
  • Age-related changes in the prostate are linked to muscle tone alterations.
  • Benign prostatic hyperplasia (BPH) is a common age-dependent condition associated with prostate changes.

Purpose of the Study:

  • To investigate the mechanisms responsible for generating stromal tone in the prostate gland.
  • To explore the role of specific cell types in prostate smooth muscle activity.

Main Methods:

  • Utilized the guinea pig model due to its prostate's smooth muscle characteristics and age-related similarities to humans.
  • Employed tension recording and electrophysiology techniques to analyze cellular activity.

Main Results:

  • Identified distinct electrical activity and cell types within the prostate.
  • Hypothesized that c-kit immunoreactive prostatic interstitial cells act as pacemakers.
  • These cells likely generate slow wave activity, initiating smooth muscle cell contractions in the guinea pig prostate.

Conclusions:

  • Prostatic interstitial cells may function analogously to interstitial cells of Cajal.
  • Understanding the electrical properties and interactions of prostatic cells is medically significant.
  • Knowledge of these mechanisms and their age-related changes is important for conditions like BPH.