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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Hospitalized pediatric parainfluenza virus infections in a medical center

Yu-Jun Hsieh1, Hsin Chin, Nan-Chang Chiu

  • 1Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|November 16, 2010
PubMed

Insights

Parainfluenza virus (PIV) infections in children present similarly across serotypes, making diagnosis challenging. However, distinct seasonal patterns for PIV serotypes 1, 2, and 3 can aid in identification.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Respiratory Medicine

Background:

  • Parainfluenza viruses (PIVs) are frequent causes of pediatric respiratory tract infections.
  • Hospitalized children often experience PIV-related illnesses, necessitating a better understanding of their clinical manifestations.

Purpose of the Study:

  • To investigate the clinical presentation of PIV infections in hospitalized children.
  • To identify clinical indicators that differentiate between PIV serotypes.

Main Methods:

  • Retrospective analysis of 206 children hospitalized with PIV infections (January 2005-December 2007).
  • Comparison of symptoms, signs, laboratory findings, and seasonal variations among PIV serotypes 1, 2, and 3.

Main Results:

  • Fever, cough, rhinorrhea, and hoarseness were common symptoms.
  • No significant differences in white blood cell counts or C-reactive protein levels were observed between serotypes.
  • PIV serotype 1 showed year-round prevalence, serotype 2 peaked in late summer/autumn, and serotype 3 was more prevalent in spring/early summer.

Conclusions:

  • Clinical presentations of PIV infections (upper respiratory tract infection to bronchopneumonia) are similar across serotypes in hospitalized children.
  • Distinct seasonal distributions of PIV serotypes offer a potential diagnostic clue.
Abstract

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