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Published on: November 18, 2022
Analyzing marginal cases in differential shotgun proteomics
Paulo C Carvalho1, Juliana S G Fischer, Jonas Perales
1Center for Technological Development in Health, Oswaldo Cruz Institute, Rio de Janeiro, Brazil. paulo@pcarvalho.com
Bioinformatics (Oxford, England)
|November 16, 2010
Abstract
Summary:
We present an approach to statistically pinpoint differentially expressed proteins that have quantitation values near the quantitation threshold and are not identified in all replicates (marginal cases). Our method uses a Bayesian strategy to combine parametric statistics with an empirical distribution built from the reproducibility quality of the technical replicates.
Availability:
The software is freely available for academic use at http://pcarvalho.com/patternlab.
