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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

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Related Experiment Video

Updated: Jun 6, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

NCBI Epigenomics: a new public resource for exploring epigenomic data sets.

Ian M Fingerman1, Lee McDaniel, Xuan Zhang

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 45 Center Drive, Bethesda, MD 20892, USA.

Nucleic Acids Research
|November 16, 2010
PubMed
Summary

The National Center for Biotechnology Information (NCBI) launched the Epigenomics database, a public resource for whole-genome epigenetic data. This database aids research into gene expression changes and their links to human diseases.

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Pattern-based Search of Epigenomic Data Using GeNemo
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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Epigenetics studies heritable changes in gene expression independent of DNA sequence.
  • Epigenetic mechanisms include histone modifications, DNA methylation, chromatin conformation, and non-coding RNAs.
  • Misregulation of epigenetic processes is linked to human diseases.

Purpose of the Study:

  • To create a comprehensive public resource for whole-genome epigenetic data.
  • To consolidate and reorganize epigenetics-specific data from existing archives.
  • To provide an intuitive interface for browsing and searching epigenetic datasets.

Main Methods:

  • Selected epigenetics data from general archives (e.g., Gene Expression Omnibus, Sequence Read Archives).
  • Reviewed, annotated, and reorganized selected data.
  • Processed raw data, mapped it to genomic coordinates, and generated visual data 'tracks'.

Main Results:

  • The Epigenomics database is now available as a public resource.
  • Data tracks are viewable using genome browsers or downloadable for local analysis.
  • The resource features an intuitive interface for data exploration based on biological attributes.

Conclusions:

  • The Epigenomics database provides a centralized, accessible platform for whole-genome epigenetic data.
  • This resource facilitates research into the role of epigenetics in human health and disease.
  • It supports both visualization and local analysis of complex epigenetic datasets.