Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cellular Adaptation I: Introduction and Atrophy

Cellular Adaptation I: Introduction and Atrophy

Cells can adapt to environmental changes to maintain function and avoid injury, a process called cellular adaptation. Adapted cells exist in a reversible intermediate state with changes in size, number, phenotype, metabolism, or function. These responses help cells meet altered physiological or pathological demands; for example, enlargement of breast and uterine tissues during pregnancy. Early adaptations may enhance function, but persistent stress eventually causes tissue damage.Types of...

Overview of Protein Metabolism

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...

Cross-bridge Cycle

Cross-bridge Cycle

As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Cellular Adaptation II: Hypertrophy

Cellular Adaptation II: Hypertrophy

Hypertrophy is the increase in the size of individual cells, resulting in the enlargement of a tissue or organ. Unlike hyperplasia, which involves an increase in cell number, hypertrophy is characterized by an increase in cell volume. This process often occurs in response to higher functional demand or hormonal stimulation, leading to the production of more structural proteins and organelles, thereby enhancing the cells' work capacity.There are two primary types of hypertrophy: physiological...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

DO-HEALTH: Vitamin D3 - Omega-3 - Home exercise - Healthy aging and longevity trial - Design of a multinational clinical trial on healthy aging among European seniors.

Contemporary clinical trials·2020

Same author

Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology.

Journal of Alzheimer's disease : JAD·2020

Same author

Precision prevention of Alzheimer's and other dementias: Anticipating future needs in the control of risk factors and implementation of disease-modifying therapies.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2020

Same author

The genetic architecture of human brainstem structures and their involvement in common brain disorders.

Nature communications·2020

Same author

An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene.

Neurobiology of aging·2020

Same author

Antidepressant Use and Progression of Mild to Moderate Alzheimer's Disease: Results from the European ICTUS Cohort.

Journal of the American Medical Directors Association·2020

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Cachexia versus sarcopenia.

Yves Rolland¹, Gabor Abellan van Kan, Sophie Gillette-Guyonnet

¹Inserm U558, University of Toulouse III, France. rolland.y@chu-toulouse.fr

Current Opinion in Clinical Nutrition and Metabolic Care

|November 16, 2010

Summary

This summary is machine-generated.

New definitions for sarcopenia and cachexia clarify distinct conditions, but distinguishing their causes in elderly patients remains challenging. Research is ongoing to validate these definitions and develop targeted therapies.

Related Experiment Videos

Last Updated: Jun 6, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Area of Science:

Gerontology
Metabolic Syndromes
Muscle Health

Background:

Sarcopenia is a multifactorial geriatric syndrome.
Cachexia is a complex metabolic syndrome characterized by muscle mass loss, often linked to underlying illness and inflammation.
Both conditions frequently affect elderly patients.

Purpose of the Study:

To summarize and discuss proposed new definitions for sarcopenia and cachexia.
To highlight the overlap between sarcopenia and cachexia.
To emphasize the prevalence of these conditions in the elderly population.

Main Methods:

Literature review of current definitions and diagnostic criteria for sarcopenia and cachexia.
Analysis of the relationship between sarcopenia and cachexia, including potential causal links.
Discussion of the clinical implications of new definitions and diagnostic approaches.

Main Results:

Sarcopenia is recognized as a geriatric syndrome, while cachexia is a metabolic syndrome with inflammation as a key feature.
Cachexia can be an underlying condition contributing to sarcopenia.
Current sarcopenia definitions integrate muscle mass and function assessments, but require further validation.

Conclusions:

Recent definitions distinguish sarcopenia and cachexia but may be indistinguishable in clinical practice.
The underlying cause of muscle mass loss may be difficult to determine.
Combined or separate therapeutic strategies targeting both conditions are warranted.