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Updated: Jun 6, 2026
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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
Genome-based and transcriptome-based molecular classification of breast cancer
Ivan Bièche1, Rosette Lidereau
1Laboratoire d'Oncogénétique, Hôpital René Huguenin, Institut Curie, St Cloud, France.
Current Opinion in Oncology
|November 16, 2010
Summary
Breast cancer
Area of Science:
- Oncology
- Genomics
- Molecular Biology
Background:
- Breast malignancies exhibit significant heterogeneity.
- This complexity arises from intricate molecular alterations.
- Understanding these molecular underpinnings is crucial.
Purpose of the Study:
- To review the molecular complexity of breast cancer.
- To highlight the role of genetic and epigenetic alterations.
- To discuss the impact of next-generation sequencing (NGS) on future breast cancer management.
Main Methods:
- Literature review of genetic and epigenetic alterations in breast cancer.
- Analysis of signaling pathways involved in breast cancer subtypes.
- Discussion of emerging next-generation sequencing (NGS) technologies.
Main Results:
- Numerous genetic and epigenetic alterations affect key signaling pathways (e.g., PI3K, NK-κB, FGF).
- These alterations have led to the identification of distinct molecular subtypes of breast cancer.
- Next-generation sequencing (NGS) offers rapid and cost-effective genome sequencing.
Conclusions:
- Future advancements in breast cancer treatment will be driven by genomic insights.
- Next-generation sequencing (NGS) will enable comprehensive genomic profiling.
- Individualized patient management will be facilitated by a complete understanding of somatic genetic alterations.
