Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary lipid cardiomyopathy.

A Zimmermann1, P Wyss, F Stocker

  • 1Institute of Pathology, University of Bern, Switzerland.

Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conserving large populations of lions - the argument for fences has holes.

Ecology letters·2013
Same author

Fibrolamellar variant of hepatocellular carcinoma does not have a better survival than conventional hepatocellular carcinoma--results and treatment recommendations from the Childhood Liver Tumour Strategy Group (SIOPEL) experience.

European journal of cancer (Oxford, England : 1990)·2013
Same author

Transverse momentum distribution and nuclear modification factor of charged particles in p+Pb collisions at sqrt[s(NN)] = 5.02 TeV.

Physical review letters·2013
Same author

Ambiguous genitalia and hypertension in a patient with congenital adrenal hyperplasia.

Internal medicine journal·2013
Same author

Charge separation relative to the reaction plane in Pb-Pb collisions at sqrt[s(NN)] = 2.76 TeV.

Physical review letters·2013
Same author

Pseudorapidity density of charged particles in p+Pb collisions at √(s(NN))=5.02 TeV.

Physical review letters·2013
Same journal

Three familial cases of fundic gland polyposis without polyposis coli.

Virchows Archiv. A, Pathological anatomy and histopathology·1993
Same journal

Myopathy and hypertrophic cardiomyopathy with selective lysis of thick filaments.

Virchows Archiv. A, Pathological anatomy and histopathology·1993
Same journal

Alpha-smooth muscle actin and other stromal markers in endometrial mucosa.

Virchows Archiv. A, Pathological anatomy and histopathology·1993
Same journal

Foamy spheroid bodies in the globus pallidus and the substantia nigra pars reticulata: an investigation on regional distribution in 56 cases without neurodegenerative diseases.

Virchows Archiv. A, Pathological anatomy and histopathology·1993
Same journal

Nature and significance of calcium oxalate crystals in normal human thyroid gland. A clinicopathological and immunohistochemical study.

Virchows Archiv. A, Pathological anatomy and histopathology·1993
Same journal

Longitudinally oriented smooth muscle cells in rabbit arteries.

Virchows Archiv. A, Pathological anatomy and histopathology·1993
See all related articles

We identified a new congenital cardiomyopathy (CMP) caused by lipid buildup in heart mitochondria. This primary lipid cardiomyopathy led to heart failure and death in a child by age 3.

Area of Science:

  • Cardiology
  • Mitochondrial Diseases
  • Genetics

Background:

  • Cardiomyopathy (CMP) encompasses diverse heart muscle diseases.
  • Mitochondrial CMPs involve mitochondrial dysfunction affecting the heart.
  • Congenital heart conditions require early diagnosis and understanding.

Observation:

  • A novel, isolated, congenital cardiomyopathy (CMP) was observed.
  • This CMP featured significant accumulation of stainable lipid within cardiomyocyte mitochondria.
  • The condition resulted in massive myocardial hypertrophy and a distinct yellow-orange discoloration of the heart muscle.

Findings:

  • The described lesion, termed primary lipid cardiomyopathy, is previously unreported.
  • The structural alteration correlated with progressive heart failure.

Related Experiment Videos

  • Affected individuals experienced fatal heart failure by age 3 years.

    • Implications:

    • Primary lipid cardiomyopathy may represent a new category of mitochondrial CMPs.
    • Understanding the pathogenic mechanisms is crucial for potential therapeutic strategies.
    • This finding expands the spectrum of known inherited cardiomyopathies.