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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

High-sensitivity C-reactive protein: an independent risk factor for left ventricular hypertrophy in patients with

Beili Shi1, Zhaohui Ni, Hong Cai

  • 1Renal Division, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Road, Shanghai 200127, China.

Journal of Biomedicine & Biotechnology
|November 16, 2010
PubMed

Insights

In lupus nephritis (LN) patients, left ventricular hypertrophy (LVH) affects 21.25%. Elevated high-sensitivity C-reactive protein (hs-CRP) is an independent risk factor for LVH in this population.

Area of Science:

  • Nephrology
  • Cardiology
  • Immunology

Background:

  • Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus.
  • Left ventricular hypertrophy (LVH) is a common cardiac abnormality.
  • Risk factors for LVH in LN patients require further investigation.

Purpose of the Study:

  • To determine the prevalence of LVH in patients with lupus nephritis.
  • To identify risk factors associated with LVH in this cohort.
  • To explore the relationship between serum high-sensitivity C-reactive protein (hs-CRP) and LVH in LN.

Main Methods:

  • 287 lupus nephritis patients were enrolled.
  • Echocardiography was performed to assess LVH.
  • Serum hs-CRP levels were measured and analyzed for correlation with LVMI using univariate and multivariate regression.

Main Results:

  • The prevalence of LVH was 21.25% among the studied LN patients.
  • Serum hs-CRP levels were significantly higher in patients with LVH.
  • hs-CRP showed a significant positive correlation with left ventricular mass index (LVMI) and was identified as an independent risk factor for LVH.

Conclusions:

  • Serum hs-CRP is independently correlated with LVMI in lupus nephritis patients.
  • Elevated hs-CRP levels are associated with LVH in LN.
  • Measuring hs-CRP may offer valuable clinical insights for assessing LVH risk in LN.
Abstract

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