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Updated: Jun 6, 2026

Pull-down of Calmodulin-binding Proteins
Published on: January 23, 2012
Cellular roles of neuronal calcium sensor-1 and calcium/calmodulin-dependent kinases in fungi
Ranjan Tamuli1, Ravi Kumar, Rekha Deka
1Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati, India. ranjantamuli@iitg.ernet.in
Abstract:
The neuronal calcium sensor-1 (NCS-1) possesses a consensus signal for N-terminal myristoylation and four EF-hand Ca(2+)-binding sites, and mediates the effects of cytosolic Ca(2+). Minute changes in free intracellular Ca(2+) are quickly transformed into changes in the activity of several kinases including calcium/calmodulin-dependent protein kinases (Ca(2+)/CaMKs) that are involved in regulating many eukaryotic cell functions. However, our current knowledge of NCS-1 and Ca(2+)/CaMKs comes mostly from studies of the mammalian enzymes. Thus far very few fungal homologues of NCS-1 and Ca(2+)/CaMKs have been characterized and little is known about their cellular roles. In this minireview, we describe the known sequences, interactions with target proteins and cellular roles of NCS-1 and Ca(2+)/CaMKs in fungi.
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