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Related Experiment Videos

Platelet count in normal, small, and anemic fetuses.

M C Van den Hof1, K H Nicolaides

  • 1Harris Birthright Research Centre for Fetal Medicine, King's College School of Medicine, Denmark Hill, London, England.

American Journal of Obstetrics and Gynecology
|March 1, 1990
PubMed
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Fetal platelet counts increase with gestational age, establishing a reference range. Thrombocytopenia (low platelet count) is linked to fetal anemia, small size, hypoxemia, and acidemia.

Area of Science:

  • Perinatal Medicine
  • Hematology
  • Fetal Physiology

Background:

  • Establishing accurate fetal platelet count reference ranges is crucial for diagnosing and managing various pregnancy complications.
  • Fetal thrombocytopenia can be associated with significant adverse outcomes, necessitating better understanding of its gestational and pathological correlates.

Purpose of the Study:

  • To establish a gestational reference range for fetal platelet counts.
  • To investigate the relationship between fetal platelet counts and conditions such as red cell isoimmunization, small for gestational age, hypoxemia, and acidemia.

Main Methods:

  • Cordocentesis was performed on 229 pregnancies for prenatal diagnosis.
  • Fetal platelet counts were analyzed and correlated with gestational age.

Related Experiment Videos

  • Platelet counts were compared between fetuses with and without red cell isoimmunization, and small for gestational age fetuses.

    • Main Results:

    • A reference range for fetal platelet count was established, showing an increase from 187 +/- 47 x 10(9)/L at 15 weeks to 274 +/- 47 x 10(9)/L at 40 weeks' gestation.
    • Severely anemic fetuses due to red cell isoimmunization were significantly thrombocytopenic.
    • Small for gestational age fetuses exhibited reduced platelet counts, correlating with fetal smallness, hypoxemia, and acidemia.

    Conclusions:

    • The study provides a vital reference range for fetal platelet counts across gestation.
    • Fetal thrombocytopenia is a significant finding in cases of severe anemia, fetal growth restriction, hypoxemia, and acidemia.
    • These findings aid in the diagnosis and management of complex fetal conditions.