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Updated: Jun 6, 2026
An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
Published on: November 28, 2010
Expression of p16 in serous ovarian neoplasms
H O Nazlioglu1, I Ercan, T Bilgin
1Department of Pathology, Uludag University School of Medicine, Bursa, Turkey. hulyaozturk@uludag.edu.tr
Purpose:
We aimed to examine p16 protein expression in ovarian serous neoplasms along with normal ovarian tissues.
Materials And Methods:
P16 expression was immunhistochemically evaluated in 86 ovarian serous neoplasms (21 cystadenomas, 20 borderline tumors and 45 carcinomas) and 21 non-neoplastic ovarian tissue. The results were also compared with histopathological grade in serous adenocarcinomas.
Results:
P16 expression rates for benign, borderline ovarian tumors and ovarian cancer were 14.2%, 85% and 86.6%, respectively. It was significantly higher in carcinomas (p < 0.001) and borderline tumors (p < 0.001) compared to cystadenomas. No immunoreactivity was found in the non-neoplastic ovarian surface epithelial cells. The percentage of p16 expression did not change significantly with histological grade in carcinomas.
Conclusion:
P16 expression is strong and widespread involving most tumor cells in serous papillary ovarian carcinomas, and is probably an early event.
