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Updated: Jun 6, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
Recurrent aneuploidy--fact or fiction
Purpose:
To evaluate the likelihood that some women are more prone to forming chromosomally abnormal embryos unrelated to age.
Methods:
The literature involving studies suggesting that predisposition to aneuploidy does exist was reviewed. In addition a new anecdotal unpublished report on a tendency to form trisomies is presented and a couple of case reports dealing with the possibility of predisposition to polyploidy are discussed.
Results:
The results of in vitro fertilization and pre-implantation diagnoses confirm the suspicion that some women are more prone to trisomies or polyploidy.
Conclusions:
In vitro fertilization with pre-implantation genetic diagnosis may help in preventing miscarriage from recurrent polyploidy but is not so valuable for recurrent trisomies.
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