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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
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Intermolecular alignment in β2-microglobulin amyloid fibrils

Galia T Debelouchina1, Geoffrey W Platt, Marvin J Bayro

  • 1Department of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Journal of the American Chemical Society
|November 17, 2010
PubMed
Summary

Dialysis-related amyloidosis involves beta2-microglobulin (β2m) fibril deposition. Solid-state NMR reveals these β2m fibrils adopt a parallel, in-register structure, indicating significant protein reorganization from its native state.

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