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Decreased pulse rate

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Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice

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Hypothyroid patient with Brugada electrocardiographic waveforms: case report.

Yong-Hui Zhao¹, Jia-Ying Zhang, Yu Xu

¹Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou, China. zhaoyonghui2000@stu.xjtu.edu.cn

Pacing and Clinical Electrophysiology : PACE

|November 17, 2010

Summary

Hypothyroidism can cause temporary Brugada electrocardiographic (Brugada-ECG) waveforms. These ECG changes resolved when thyroid function normalized, suggesting a link between thyroid hormones and heart electrical activity.

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Area of Science:

Cardiology
Endocrinology
Electrophysiology

Background:

Brugada electrocardiographic (Brugada-ECG) patterns are associated with an increased risk of sudden cardiac death.
Thyroid dysfunction can affect cardiac function and electrophysiology.

Observation:

A 46-year-old man presented with hypothyroidism and Brugada-ECG waveforms in leads V1-V3.
The patient had no personal or family history of arrhythmias or syncope.

Findings:

Brugada-ECG waveforms resolved completely upon normalization of thyroid function.
This suggests a reversible, secondary cause for the Brugada-ECG pattern.

Implications:

Hypothyroidism may induce secondary Brugada-ECG waveforms through effects on myocardial ion channels.
This highlights the importance of evaluating thyroid function in patients presenting with Brugada-ECG patterns.
Further research is needed to elucidate the precise mechanisms linking thyroid hormones and cardiac ion channel function.