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Related Experiment Video

Updated: Jun 6, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
05:28

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study.

Sari Karlsson1, Milja Heikkinen, Ville Pettilä

  • 1Department of Intensive Care Medicine, Tampere University Hospital, Teiskontie 35, 33521 Tampere, Finland. sari.karlsson@pshp.fi

Critical Care (London, England)
|November 17, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...

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Procalcitonin (PCT) levels indicate sepsis severity, but a significant decrease in PCT concentration over 72 hours is a stronger predictor of survival in critically ill patients than initial levels.

Area of Science:

  • Biochemistry
  • Critical Care Medicine
  • Infectious Diseases

Background:

  • Severe sepsis and septic shock are life-threatening conditions requiring accurate prognostic markers.
  • Procalcitonin (PCT) is a biomarker investigated for its role in predicting outcomes in sepsis.

Purpose of the Study:

  • To evaluate the predictive value of procalcitonin (PCT) for survival in adult patients with severe sepsis and septic shock.
  • To determine if PCT levels correlate with sepsis severity and patient outcomes.

Main Methods:

  • Prospective study of 242 adult patients with severe sepsis/septic shock.
  • Procalcitonin (PCT) levels measured at baseline and 72 hours.
  • Analysis of PCT concentrations in relation to infection type, blood culture results, septic shock, and patient survival.

Related Experiment Videos

Last Updated: Jun 6, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
05:28

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

Main Results:

  • Higher PCT concentrations were observed in community-acquired infections, positive blood cultures, and septic shock.
  • Initial PCT levels did not significantly differ between survivors and non-survivors.
  • A decrease in PCT concentration of >50% by 72 hours was associated with significantly lower mortality (12.2% vs. 29.8%).

Conclusions:

  • While PCT concentrations reflect sepsis severity, a substantial decrease is a more critical indicator of improved survival.
  • Monitoring PCT concentration changes offers valuable prognostic information beyond absolute values in severe sepsis.