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Updated: Jun 6, 2026

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
Published on: September 26, 2011
Viral sequence analysis from HIV-infected mothers and infants: molecular evolution, diversity, and risk factors for
Philip L Bulterys1, Sudeb C Dalai, David A Katzenstein
1Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305-4200, USA.
Abstract:
Great progress has been made in understanding the pathogenesis, treatment, and transmission of HIV and the factors influencing the risk of mother-to-child transmission (MTCT). Many questions regarding the molecular evolution and genetic diversity of HIV in the context of MTCT remain unanswered. Further research to identify the selective factors governing which variants are transmitted, how the compartmentalization of HIV in different cells and tissues contributes to transmission, and the influence of host immunity, viral diversity, and recombination on MTCT may provide insight into new prevention strategies and the development of an effective HIV vaccine.
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