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Published on: January 22, 2019
Protein kinase affinity reagents based on a 5-aminoindazole scaffold
Ratika Krishnamurty1, Amanda M Brock, Dustin J Maly
1Department of Chemistry, Box 351700, University of Washington, Seattle, WA 98195-1700, United States.
Bioorganic & Medicinal Chemistry Letters
|November 17, 2010
Abstract
None:
Affinity reagents that target protein kinases are powerful tools for signal transduction research. Here, we describe a general set of kinase ligands based on a 5-aminoindazole scaffold. This scaffold can readily be derivatized with diverse binding elements and immobilized analogs allow selective enrichment of protein kinases from complex mixtures.

