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A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus
08:03

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus

Published on: March 28, 2017

Systematic review and meta-analysis of the significance of heterogeneous vancomycin-intermediate Staphylococcus

Sebastiaan J van Hal1, David L Paterson

  • 1Department of Microbiology and Infectious Diseases, Liverpool Hospital, Liverpool BC, NSW, Sydney, Australia. Sebastian.vanHal@sswahs.nsw.gov.au

Antimicrobial Agents and Chemotherapy
|November 17, 2010
PubMed

Insights

Heteroresistant vancomycin-intermediate Staphylococcus aureus (hVISA) infections are linked to higher treatment failure rates. However, mortality rates for hVISA are similar to vancomycin-sensitive Staphylococcus aureus (VSSA) infections, indicating a need for further therapeutic research.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Clinical Medicine

Background:

  • Heteroresistant vancomycin-intermediate Staphylococcus aureus (hVISA) poses a growing clinical challenge.
  • Published prevalence of hVISA is approximately 1.3%.

Purpose of the Study:

  • To analyze the clinical associations and outcomes of hVISA infections.
  • To compare treatment failure and mortality rates between hVISA and vancomycin-sensitive Staphylococcus aureus (VSSA) infections.

Main Methods:

  • Literature review and meta-analysis of published studies on hVISA prevalence and outcomes.
  • Statistical analysis of clinical data, including infection types and treatment responses.

Main Results:

  • hVISA infections are associated with high-inoculum infections and increased glycopeptide treatment failure.
  • The failure rate for hVISA infections was 2.37 times higher than for VSSA infections (95% CI, 1.53 to 3.67).
  • No significant difference in 30-day mortality rates was observed between hVISA and VSSA infections (OR, 1.18; 95% CI, 0.81 to 1.74).

Conclusions:

  • hVISA infections present a significant risk for treatment failure, particularly with glycopeptide antibiotics.
  • While mortality is not elevated, the increased failure rate underscores the need for optimized therapeutic strategies for hVISA.
  • Further research is essential to determine the optimal treatment for hVISA infections.

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