Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tracheostomy Decannulation01:21

Tracheostomy Decannulation

Tracheostomy decannulation is a significant milestone in the liberation of mechanically ventilated patients. Despite its importance, there is no universally accepted protocol for this procedure. This demands an evidence-based, individualized approach.
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk-adapted therapy guided by human papillomavirus (HPV) circulating tumor DNA in HPV-positive oropharyngeal cancer (ReACT 1.0): an exploratory phase II trial.

Nature communications·2026
Same author

Financial instability, insurance, and transportation influence timely head and neck cancer care in the United States: Patient and healthcare worker perspectives.

Oral oncology·2025
Same author

A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue-Modified Viral HPV DNA.

Clinical cancer research : an official journal of the American Association for Cancer Research·2024
Same author

A metabolomics pipeline highlights microbial metabolism in bloodstream infections.

Cell·2024
Same author

Personalized ctDNA for Monitoring Disease Status in Head and Neck Squamous Cell Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2024
Same author

Phase II trial of vaccination with autologous, irradiated melanoma cells engineered by adenoviral mediated gene transfer to secrete granulocyte-macrophage colony stimulating factor in patients with stage III and IV melanoma.

Frontiers in oncology·2024
Same journal

Pathology quiz case 2.

Archives of otolaryngology--head & neck surgery·2014
Same journal

Pathology quiz case 1.

Archives of otolaryngology--head & neck surgery·2014
Same journal

Radiology quiz case 1: diagnosis.

Archives of otolaryngology--head & neck surgery·2013
Same journal

Pair of red and green macaws.

Archives of otolaryngology--head & neck surgery·2013
Same journal

Pathology quiz case 2: diagnosis.

Archives of otolaryngology--head & neck surgery·2013
Same journal

About this journal.

Archives of otolaryngology--head & neck surgery·2013
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Modified Radical Neck Dissection for Cervical Metastasis
06:05

Modified Radical Neck Dissection for Cervical Metastasis

Published on: February 20, 2026

Neck dissection after chemoradiotherapy: timing and complications.

Laura A Goguen1, Claudia I Chapuy, Yi Li

  • 1Division of Otolaryngology, Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA. lgoguen@partners.org

Archives of Otolaryngology--Head & Neck Surgery
|November 17, 2010
PubMed
Summary
This summary is machine-generated.

Performing neck dissection 12 weeks or more after chemoradiotherapy (CRT) is safe. This timing did not increase surgical complications or negatively impact disease control and survival for head and neck cancer patients.

Related Experiment Videos

Last Updated: Jun 6, 2026

Modified Radical Neck Dissection for Cervical Metastasis
06:05

Modified Radical Neck Dissection for Cervical Metastasis

Published on: February 20, 2026

Area of Science:

  • Oncology
  • Head and Neck Surgery
  • Radiation Oncology

Background:

  • Neck dissection (ND) is a critical procedure for head and neck cancer management post-chemoradiotherapy (CRT).
  • The optimal timing for ND after CRT remains a subject of investigation regarding safety and efficacy.

Purpose of the Study:

  • To evaluate the incidence of complications following post-CRT ND.
  • To determine if the timing of ND (less than 12 weeks vs. 12 weeks or more) influences complication rates.
  • To assess the impact of ND timing on disease control and patient survival.

Main Methods:

  • Retrospective analysis of 105 head and neck cancer patients undergoing ND after CRT.
  • Comparison of complication rates and survival outcomes between patients receiving ND less than 12 weeks versus 12 weeks or more after CRT.
  • Multivariate analysis to identify factors associated with complications.

Main Results:

  • The group undergoing ND 12 weeks or more after CRT had a significantly lower incidence of overall complications (P = .04).
  • Radical ND and higher radiation doses were associated with increased complications; induction chemotherapy correlated with fewer wound complications.
  • No significant differences were observed in overall survival, progression-free survival, or regional relapse rates between the early and delayed ND groups.

Conclusions:

  • Neck dissection can be safely performed 12 weeks or more after CRT.
  • Delayed ND does not appear to compromise surgical safety or oncologic outcomes.
  • Patient factors and surgical approach significantly influence complication rates.