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Updated: Jun 6, 2026

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

Cutaneous CD4+/CD56+ hematodermic neoplasm.

Ilkin Zindanci¹, Mukaddes Kavala, Nesimi Buyukbabani

¹Department of Dermatology, Goztepe Training and Resach Hospital, Istanbul, Turkey. ilkin.dr@gmail.com

Indian Journal of Dermatology, Venereology and Leprology

|November 17, 2010

Summary

CD4+/CD56+ hematodermic neoplasm, a rare and aggressive cancer, presents unique diagnostic challenges. This case highlights a cheek presentation without leukemic spread, offering insights into its varied clinical behavior.

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Area of Science:

Hematology
Oncology
Dermatology

Background:

CD4+/CD56+ hematodermic neoplasm, previously termed blastic NK cell lymphoma, is a rare and aggressive malignancy.
It is characterized by the co-expression of CD4 and CD56 markers in neoplastic cells, lacking other specific T or NK cell markers.
The neoplasm frequently involves the skin, carries a risk of leukemic dissemination, and has a generally poor prognosis.

Observation:

This report details a case of a 48-year-old woman diagnosed with CD4+/CD56+ hematodermic neoplasm.
The patient presented with a cutaneous lesion on her cheek.
Notably, the presentation occurred without evidence of leukemic infiltration.

Findings:

The case underscores the diagnostic criteria for CD4+/CD56+ hematodermic neoplasm, emphasizing the co-expression of CD4 and CD56.
It demonstrates a rare clinical presentation of this neoplasm primarily involving the skin.
The absence of leukemic dissemination in this specific case provides valuable data on the disease's spectrum.

Implications:

This case contributes to understanding the clinical variability of CD4+/CD56+ hematodermic neoplasm.
It highlights the importance of considering this rare diagnosis in patients with cutaneous lesions and the specified immunophenotype.
Further research into rare presentations may improve diagnostic strategies and prognostic assessments for this aggressive neoplasm.