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Related Experiment Video

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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

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Fetal varicella syndrome.

S Ramachandra¹, Arun Kumar Metta, Nayeem Sadath Haneef

¹Department of Dermatology, Venereology and Leprology, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda, Andhra Pradesh, India. dr_sramoo@yahoo.co.in

Indian Journal of Dermatology, Venereology and Leprology

|November 17, 2010

Summary

This summary is machine-generated.

Fetal varicella syndrome, a rare newborn condition, can cause scars and defects from maternal chickenpox in early pregnancy. This case highlights a newborn with characteristic skin lesions linked to first-trimester maternal varicella infection.

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Area of Science:

Pediatrics
Maternal-Fetal Medicine
Teratology

Background:

Fetal varicella syndrome (FVS) is a rare congenital condition.
It results from maternal varicella (chickenpox) or zoster (shingles) infection during early gestation.
FVS can lead to significant developmental abnormalities in the newborn.

Observation:

This report details a specific case of FVS in a neonate.
The patient presented with a distinctive linear, depressed, erythematous scar.
The scar was located on the left forearm and axillary fold.

Findings:

The patient's presentation was consistent with FVS.
A maternal history of chickenpox during the first trimester of pregnancy was confirmed.
The observed cutaneous scar is a known manifestation of FVS.

Implications:

This case underscores the importance of recognizing FVS in newborns with characteristic lesions.
Early identification of FVS is crucial for appropriate management and counseling.
Understanding the teratogenic effects of maternal varicella infection is vital for prenatal care.