Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

RNA-seq03:21

RNA-seq

11.6K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
11.6K
Epigenetic Regulation01:37

Epigenetic Regulation

3.6K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.6K
Epigenetic Regulation01:46

Epigenetic Regulation

33.3K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.3K
Histone Modification02:32

Histone Modification

15.7K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
15.7K
RNA Stability01:53

RNA Stability

35.5K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.5K
RNA Editing02:23

RNA Editing

9.7K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis.

Cancer discovery·2019
Same author

Regulation of Gene Expression by N<sup>6</sup>-methyladenosine in Cancer.

Trends in cell biology·2019
Same author

Molecular mechanisms of atomic layer etching of cobalt with sequential exposure to molecular chlorine and diketones.

Journal of vacuum science & technology. A, Vacuum, surfaces, and films : an official journal of the American Vacuum Society·2019
Same author

miR‑146a‑5p expression is upregulated by the CXCR4 antagonist TN14003 and attenuates SDF‑1‑induced cartilage degradation.

Molecular medicine reports·2019
Same author

Author Correction: Anti-tumour immunity controlled through mRNA m<sup>6</sup>A methylation and YTHDF1 in dendritic cells.

Nature·2019
Same author

Total Syntheses of (+)-Sarcophytin, (+)-Chatancin, (-)-3-Oxochatancin, and (-)-Pavidolide B: A Divergent Approach.

Angewandte Chemie (International ed. in English)·2019
Same journal

Allosteric disordering of eIF2B regulates the integrated stress response.

Nature chemical biology·2026
Same journal

A tail of two ligases.

Nature chemical biology·2026
Same journal

Non-canonical cytochrome P450 enzymes expand the diversity of bacterial hemoproteins.

Nature chemical biology·2026
Same journal

Image-guided activation of drugs with electromagnetic radiation.

Nature chemical biology·2026
Same journal

Detecting protein fluctuations at scale.

Nature chemical biology·2026
Same journal

Revealing the Wnt signalosome.

Nature chemical biology·2026
See all related articles

Related Experiment Video

Updated: Dec 25, 2025

Author Spotlight: RNAi Inheritance and ChIP in C. elegans
10:28

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

4.5K

Grand challenge commentary: RNA epigenetics?

Chuan He1

  • 1Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, USA. chuanhe@uchicago.edu

Nature Chemical Biology
|November 17, 2010
PubMed
Summary
This summary is machine-generated.

Dynamic RNA modifications offer more than structural tuning. Research into these post-transcriptional RNA modification pathways reveals novel gene regulation mechanisms at the RNA level.

More Related Videos

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis
08:50

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis

Published on: May 14, 2020

7.1K
CARIP-Seq and ChIP-Seq: Methods to Identify Chromatin-Associated RNAs and Protein-DNA Interactions in Embryonic Stem Cells
11:13

CARIP-Seq and ChIP-Seq: Methods to Identify Chromatin-Associated RNAs and Protein-DNA Interactions in Embryonic Stem Cells

Published on: May 25, 2018

10.1K

Related Experiment Videos

Last Updated: Dec 25, 2025

Author Spotlight: RNAi Inheritance and ChIP in C. elegans
10:28

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

4.5K
Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis
08:50

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis

Published on: May 14, 2020

7.1K
CARIP-Seq and ChIP-Seq: Methods to Identify Chromatin-Associated RNAs and Protein-DNA Interactions in Embryonic Stem Cells
11:13

CARIP-Seq and ChIP-Seq: Methods to Identify Chromatin-Associated RNAs and Protein-DNA Interactions in Embryonic Stem Cells

Published on: May 25, 2018

10.1K

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Post-transcriptional RNA modifications are increasingly recognized for their dynamic nature.
  • These modifications extend beyond simple RNA structure and function regulation.

Purpose of the Study:

  • To explore the functional significance of dynamic RNA modifications.
  • To investigate the potential for novel gene regulation through RNA modifications.

Main Methods:

  • Analysis of RNA modification pathways.
  • Functional studies of modified RNAs.

Main Results:

  • RNA modifications exhibit dynamic properties.
  • These modifications play roles beyond RNA structure and function.

Conclusions:

  • Understanding RNA modification pathways is key to uncovering new gene regulatory layers.
  • RNA-level gene regulation is a significant area for future research.