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Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

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Regulatory ripples.

Yasmine Belkaid¹, Wanjun Chen

¹Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. ybelkaid@niaid.nih.gov

Nature Immunology

|November 17, 2010

Summary

This summary is machine-generated.

Interleukin 35 and Interleukin 10 induce specialized regulatory T cells, termed iTR35 cells. These cells may play a crucial role in establishing infectious tolerance.

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Area of Science:

Immunology
Cell Biology

Background:

Regulatory T cells (Tregs) exhibit diverse functional and developmental phenotypes.
Interleukin 35 (IL-35) is an immunosuppressive cytokine produced by Tregs.

Discussion:

IL-35, in conjunction with Interleukin 10 (IL-10), promotes the development of a distinct Treg subset.
This novel Treg subset is designated as 'iTR35 cells'.

Key Insights:

The induction of iTR35 cells is mediated by the combined action of IL-35 and IL-10.
iTR35 cells represent a newly identified cell type within the regulatory T cell family.

Outlook:

iTR35 cells are implicated in the mechanism of infectious tolerance.
Further research is warranted to elucidate the precise functions and therapeutic potential of iTR35 cells in immune regulation.