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Related Concept Videos

Exocytosis00:51

Exocytosis

Exocytosis is used to release material from cells. Like other bulk transport mechanisms, exocytosis requires energy.
Exocytosis00:50

Exocytosis

Exocytosis is a process that releases molecules outside the cell. Like other bulk transport mechanisms, exocytosis requires energy.
Exocytosis is the opposite of endocytosis, which brings molecules inside the cell. Sometimes, the released materials are signaling molecules. For example, neurons typically use exocytosis to release neurotransmitters. Cells also use exocytosis to insert proteins such as ion channels into their cell membranes, secrete proteins for use in the extracellular matrix, or...
Membrane Fluidity01:26

Membrane Fluidity

Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Assembly of the Lipid Bilayer in the ER01:28

Assembly of the Lipid Bilayer in the ER

Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...

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Related Experiment Video

Updated: Jun 6, 2026

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells
10:21

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells

Published on: September 16, 2020

Lipid dynamics in exocytosis.

S Chasserot-Golaz1, J R Coorssen, F A Meunier

  • 1Département Neurotransmission & Sécrétion Neuroendocrine, Institut des Neurosciences Cellulaires et Intégratives (UPR-3212), Centre National de Recherche Scientifique, Université de Strasbourg, 5 rue Blaise Pascal, 67084 Strasbourg, France. chasserot@unistra.fr

Cellular and Molecular Neurobiology
|November 17, 2010
PubMed
Summary
This summary is machine-generated.

Lipids actively regulate exocytosis, the process of releasing cellular contents. This study highlights the crucial roles of cholesterol, phosphoinositides, and phosphatidic acid in this essential biological mechanism.

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Area of Science:

  • Cell Biology
  • Neuroscience
  • Biochemistry

Background:

  • Regulated exocytosis is vital for neuronal and hormonal signaling.
  • It involves SNARE protein complexes mediating vesicle fusion with the plasma membrane.
  • The role of lipids in exocytosis has been historically underappreciated compared to proteins.

Purpose of the Study:

  • To highlight recent advances in understanding the active role of lipids in exocytosis.
  • To focus on specific lipids involved in regulating this process.

Main Methods:

  • Review of current literature on lipid involvement in exocytosis.
  • Focus on key lipids: cholesterol, 3'-phosphorylated phosphoinositides, and phosphatidic acid.

Main Results:

  • Lipids play an active, rather than passive, role in exocytosis.
  • Cholesterol influences membrane fluidity and SNARE complex formation.
  • Phosphoinositides and phosphatidic acid are critical for vesicle tethering and fusion.

Conclusions:

  • Lipids are essential regulators of exocytosis, working alongside SNARE proteins.
  • Understanding lipid roles provides new avenues for studying cellular communication.
  • Further research into lipid mediators can uncover novel therapeutic targets.